A Michigan Medicine dietician explains how the popular low-carb regimen can get results — as well as related risks everyone should know. Touted by celebrities as a quick way to lose substantial weight, the ketogenic diet might seem counterintuitive to good heart health. Fruits, root vegetables, grain products and legumes all are prohibited. The intake is designed to trigger the metabolic state of ketosis, a process that occurs when the body burns off fat as an alternate source of energy. A keto diet can also lower elevated blood sugar linked to artery-damaging inflammation. Proteins comprise 20 percent — and carbohydrates make up just 5 percent. Cutting out low-quality carbs found in soft drinks and white bread, for instance, is a good idea for anyone, Ryskamp says. Sugar and starches raise the risk for obesity, diabetes and heart disease. Healthful, too, is a steady intake of green vegetables such as broccoli, celery, kale and spinach — all of which are permitted on the keto diet. Those foods matter: A study of low-carb dieters found that those who focused on vegetable-based sources of fat and protein had a 23 percent lower risk of heart disease than those who relied more heavily on meat.
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Recent case reports showed improvement of cardiomyopathy following a ketogenic diet. Two siblings girl and boy, 7- and 5-year-old, both affected with GSD IIIa, developed severe and rapidly worsening left ventricular hypertrophy in the first years of life, while treated with frequent diurnal and nocturnal hyperproteic meals followed by orally administered uncooked cornstarch. A diet rich in fats as well as proteins and poor in carbohydrates could be a beneficial therapeutic choice for GSD III with cardiomyopathy. Future research is needed to confirm the beneficial effect of this treatment and to design treatment strategies with the aim to provide alternative source of energy and prevent glycogen accumulation. Clinically patients show fasting hypoglycemia, hyperlipidemia, growth delay, enlargement of liver and both skeletal muscles, and heart involvement. Cardiomyopathy with left ventricular hypertrophy is a relatively common finding although with variable severity and progression. It may be associated with potential risk of serious arrhythmia and symptomatic heart failure Austin et al. Functionally these patients have only partial glycogenolysis, while glycolysis and gluconeogenesis are preserved.