This table also includes supporting evidence from human studies from the same time frame that evaluate the treatment efficacy of the ketogenic diet for other CNS injuries or disorders, such as epilepsy, hypoxia, and for stroke. Recovery nutritional strategy utilizes an alternative metabolic pathway, and there is brain data on issues such injury dosing and duration of either diet-controlled ketosis or exogenous administration of agents that enhance ketone production. For, and Diet. For completeness and towards discussion brain safety, a keto number of human trials recovery also successfully injury ketogenic diets for management of both type I and type II diabetes, with a small sample of such trials referenced here. Reger, M. At that same time, keto injury impairs the brains ability to use glucose. Search for terms x. External link. Voustianiouk, D. Warning You have reached the maximum number diet saved studies This shift has profound effects on metabolism for both the sick and healthy alike.
NCBI Bookshelf. Originally developed to mimic biochemical changes associated with starvation or periods of limited food availability, the ketogenic diet is composed of 80—90 percent fat and provides adequate protein but limited carbohydrates Gasior et al. Under some circumstances, like fasting, glucose is not available because the diet contains insufficient amounts of carbohydrates to meet metabolic needs. Consequently, fatty acid oxidation becomes favored, and the liver converts fat into fatty acids and ketone bodies that serve as an efficient alternative fuel for brain cells. Although fatty acids cannot cross the blood-brain barrier, these three ketone bodies can enter the brain and serve as an energy source. Since their development to treat epileptic children in , ketogenic diets have been most studied in the context of pediatric epilepsy syndromes Kossoff et al. Seizures can be decreased by effects on GABA such as increasing its synthesis or decreasing its metabolism and breakdown.
Study record managers: refer to the Data Element Definitions if submitting registration or results information. Several animal models have demonstrated the effectiveness of ketones in brain injury to decrease the size of contusion, improving cortical ATP levels, reduced brain edema and cellular apoptosis. Evaluation of carbohydrate free diet has been done in traumatic brain injury patients and it was noted to not cause fluctuations in blood glucose. The present study focuses on identifying the safety and feasibility of KD in traumatic brain injury patients. This pilot project data will be utilized to design future randomized clinical trials. Based on the safety data, further trials will be conducted to evaluate the effectiveness of KD in traumatic brain injury patients and its effectiveness in controlling elevated intracranial pressure.