Thank you for visiting nature. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. A Corrigendum to this article was published on 05 August Cardiovascular disease risk is associated with excess body weight and elevated plasma free fatty acid FFA concentrations. This study examines how an alternate-day fasting ADF diet high HF or low LF in fat affects plasma FFA profiles in the context of weight loss and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 women BMI 30— Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry DXA. Total and individual FFA and plasma lipid concentrations were measured before and after weight loss. Depending on the macronutrient composition of a diet, weight loss with an ADF diet decreases FFA concentrations through potentially different mechanisms. Higher FFA concentrations in plasma have been associated with atherosclerosis, thrombosis and hypertension 1, 3, 4.
Fatty acid composition in blood and adipose tissue AT is a useful biomarker of dietary fat quality. Fatty acid FA composition in plasma lipids and adipose tissue AT are widely used as biomarkers of dietary fat quality. This discrepancy among FA biomarkers may in part be due to the fact that SFA are non-essential and are thus to some extent endogenously synthesized. Interventional studies suggest that hepatic DNL is induced by a high-carbohydrate and low-fat diet [ 3 ], leading to increased proportions of circulating and other even-chain SFA [ 4, 5, 6 ]. Further, overfeeding studies suggest that hepatic DNL is increased in healthy subjects overfed with carbohydrates [ 7 ]. Observational data are scarce, but in a US population of elderly individuals, there was a positive association between higher carbohydrate intake replacing fat and alcohol, and plasma SFA in phospholipids PL [ 8, 9, 10 ]. Yet no studies have been conducted in Scandinavian populations, despite that several Swedish prospective cohort studies have demonstrated a direct link between serum SFA especially and diabetes and CVD [ 12, 13 ]. To interpret these associations between serum SFA and increased risk of disease outcomes, dietary and food intake data of carbohydrates and sugars are of clear interest. The study population has been described previously [ 14 ]. The men were recruited from a cohort study of year-old men and women 60YO who had a baseline investigation between and regarding risk factors for cardiovascular disease. Men were divided into three groups based on tertiles of their fasting insulin concentrations. Requests to participate in a study concerning diet and metabolic syndrome were overall randomly sent until positive responders reached approximately men in each group.
High carb diets and serum free fatty acids opinion you are
Despite this adverse effect, weight loss was not greater in the High Fat group. This increases vasospasm, vasoconstriction, and blood viscosity and can cause development of diseases associated with these conditions Patterson et al. Trafficking of dietary fat in obesity-prone and obesity-resistant rats. This was done to reduce possible differences due to natural variations seen through the phases of the cycle. Makiguchi, M. Fernandez-Elias, V. Each diet was consumed on two consecutive days, separated by a wash-out period.