David E. Information regarding the early effects of obesogenic diets on feeding patterns and behaviors is limited. To improve knowledge regarding the etiology of obesity, young male Wistar rats were submitted to high-fat HFD or regular chow diets RCDs for 14 days. Various metabolic parameters were continuously measured using metabolic chambers. Total weight gain was similar between groups, but heavier visceral fat depots and reduced weight of livers were found in HFD rats. Total calorie intake was increased while individual feeding bouts were shorter and of higher calorie intake in response to HFD. Ambulatory activity and sleep duration were decreased in HFD rats during passive and active phase, respectively. Acylated and unacylated ghrelin levels were unaltered by the increased calorie intake and the early changes in body composition. This indicates that at this early stage, the orexigenic signal did not adapt to the high-calorie content of HFD.
A Hypercaloric pellet-diet cycle induces obesity and co-morbidities in wistar rats. Leopoldo; Ana P. Lima-Leopoldo; Renata A. Nogueira; Antonio C. Correspondence to. The present study was carried to develop and analyze the consequences of hypercaloric pellet-diet cycle that promotes obesity in rats. The ND group received commercial Labina rat feeding while the HD animals received a cycle of five hypercaloric diets over a week period. The hypercaloric pellet diet cycle promoted an increase in body weight and fat, systolic arterial pressure and a high serum level of glucose, triacylglycerol, insulin and leptin. The HD group also presented an impaired glucose tolerance. In conclusion, the results of this study show that the hypercaloric pellet-diet cycle promoted obesity in Wistar rats and displayed several characteristics that are commonly associated with human obesity, such as high arterial pressure, insulin resistance, hyperglycaemia, hyperinsulinaemia, hyperleptinaemia and dyslipidaemia.
Care 13, — Effects of ageing high-fat the palatagle balance of food-restricted rats. Palatable, J. However, considering that free-choice group offspring were fed with a hypercaloric diet after weaning, the decreased endocannabinoid levels at birth cannot be directly correlated to the development of adipogenesis in adulthood. Journal overview. Maternal obesity induced by diet in rats diet influences central processes regulating food intake in offspring. Stern, D.